#21 Insulin Resistance in Different Tissues and Why It Is Important to MOVE Your Body

In this episode, Dr. Grady and Dr. Garrett discuss the mechanisms of insulin resistance in various tissues in the body (muscle, liver, fat). This leads to several digressions about lifestyle habits that will that will affect these tissues directly to improve insulin resistance, such as exercise and muscle glucose metabolism. We also talk about what "Bursts Our Beta Cells" and a diabetic win that we recently had.

 

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Time Stamps:

0:36 - Grady's "Burst My Beta Cells": Insurance and Pharmacies

9:53 - Garrett's "Bursts My Beta Cells": Margaritas, Celebration and T1D

15:03 - Diet Induced Obesity for Insulin Resistance (IR) Models and Studies

22:04 - Importance of Muscle Physiology

25:50 - Moving Your Body for Metabolism and Insulin Sensitivity

35:10 - 4 Major IR Models within Myocytes (Muscle Cells)

37:19 - Intracellular Lipids within Myocytes (Muscle Cells)

41:53 - Explanation on Glucose Sparing

45:07 - Athlete Paradox with Intracellular Lipids

50:06 - TAGs and Lipid Panels in Context of Muscle Physiology

55:10 - Mitochondria Dysfunction within Myocytes

1:02:38 - IR within Hepatocytes (Liver Cells) Definition

1:12:58 - IR in the Liver and NAFLD

1:15:43 - IR Liver Leads to Increased Lipogenesis and Transportation

1:19:33 - Brief Discussion on IR and Adipose Tissue

1:23:58 - Personal Diabetes Win

 

Resources/Links Discussed in the episode:

Small, Lewin, et al. “Modeling Insulin Resistance in Rodents by Alterations in Diet: What Have High-Fat and High-Calorie Diets Revealed?” American Journal of Physiology-Endocrinology and Metabolism, vol. 314, no. 3, 2018, doi:10.1152/ajpendo.00337.2017.