#5 Management of Type 2 Diabetes

Episode #5 Management of Type 2 Diabetes

Join Dr. Grady and Garrett, both Type 1 Diabetics, as they talk about blood sugar, overall health, and how to take control of your health to gain the freedom to live the life you deserve.

In this episode, Dr. Donohoe and Garrett discuss the management of Type 2 Diabetes and the mechanisms of how diet and exercise are such powerful tools when trying to achieve optimal blood glucose levels. We also get into sleep and stress management in regards to blood sugar.

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Resources/Links Discussed in the episode:

• Richter, E.A., & Hargreaves, M., (2013). Exercise, GLUT4, and Skeletal Muscle Glucose Uptake. Physiological Reviews; 93(3):993-1017. https://www.physiology.org/doi/full/10.1152/physrev.00038.2012?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

• Niu, Y., et al., (2017). Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner. BBA Molecular Basis of Disease; 1863(9):2372-2381 https://www.sciencedirect.com/science/article/pii/S092544391730220X?via%3Dihub

• Yin, J., Xing, H., & Ye, J., (2008). Efficacy of Berberine in Patients with Type 2 Diabetes. Metabolism; 57(5): 712-717. https://www.ncbi.nlm.nih.gov/pubmed/18442638

• Wang, H., Zhu, C., Ying, Y., Luo, L., Huang, D., & Luo, Z., (2018). Metformin and berberine, two versatile drugs in the treatment of common metabolic diseases. Oncotarget; 9(11): 10135-10146.
  https://www.ncbi.nlm.nih.gov/pubmed/29515798
• De Souza, JFT., Dattilo, M., de Mello, MT., Tuflk, S.,&  Antunes, HKM (2017). High-Intensity Interval Training Attenuates Insulin Resistance Induced by Sleep Deprivation in Healthy Males. Front Physiol; 8: 992.
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725446/
• Ahmed, A. Bakrudeen Ali, et al. “In Vitro Callus and in Vivo Leaf Extract of Gymnema Sylvestre Stimulate β-Cells Regeneration and Anti-Diabetic Activity in Wistar Rats.” Phytomedicine, vol. 17, no. 13, 2010, pp. 1033–1039., doi:10.1016/j.phymed.2010.03.019.
• Al‐Romaiyan, Altaf, et al. “A Novel            Gymnema Sylvestre Extract Protects Pancreatic Beta‐Cells from Cytokine‐Induced Apoptosis.” Phytotherapy Research, 2019, doi:10.1002/ptr.6512.
• Kuo, Daih-Huang, et al. “Body Weight Management Effect of Burdock (Arctium Lappa L.) Root Is Associated with the Activation of AMP-Activated Protein Kinase in Human HepG2 Cells.” Food Chemistry, vol. 134, no. 3, 2012, pp. 1320–1326., doi:10.1016/j.foodchem.2012.03.023.
• Lan, Jiarong, et al. “Meta-Analysis of the Effect and Safety of Berberine in the Treatment of Type 2 Diabetes Mellitus, Hyperlipemia and Hypertension.” Journal of Ethnopharmacology, vol. 161, 2015, pp. 69–81., doi:10.1016/j.jep.2014.09.049.
• Lee, Woo Je. “α-Lipoic Acid Increases Insulin Sensitivity by Activating AMPK in Skeletal Muscle.” Biochemical and Biophysical Research Communications, vol. 332, no. 3, 2005, pp. 885–891., doi:10.1016/j.bbrc.2005.05.035.
• Magistrelli, Ashley, and Jo Carol Chezem. “Effect of Ground Cinnamon on Postprandial Blood Glucose Concentration in Normal-Weight and Obese Adults.” Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 11, 2012, pp. 1806–1809., doi:10.1016/j.jand.2012.07.037.
• Viollet, Benoit. “Targeting the AMPK Pathway for the Treatment of Type 2 Diabetes.” Frontiers in Bioscience, Volume, no. 14, 2009, p. 3380., doi:10.2741/3460.
• Wei, Wei, et al. “A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.” European Journal of Endocrinology, vol. 166, no. 1, 2012, pp. 99–105., doi:10.1530/eje-11-0616.